ISN1 Nucleotidases and HAD Superfamily Protein Fold: In silico Sequence and Structure Analysis
نویسندگان
چکیده
cN-II class of 5' purine nucleotidases exhibit specificity for IMP/GMP and belong to the HAD (haloacid dehalogenase) superfamily of hydrolases. The recently identified ISNI class of IMP specific 5'-nucleotidases occurring in yeast, fungi and certain Plasmodia lack sequence homology with the cN-II class of enzymes. We show from analysis of motif and fold conservation that ISN1s also belong to the HAD superfamily. This identification adds a new novel member to this superfamily.
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عنوان ژورنال:
- In silico biology
دوره 7 2 شماره
صفحات -
تاریخ انتشار 2007